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Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis: Analysis of Safety and Fungicidal Activity

Autor(es):	GOLDANI, Luciano () et al. () Section of Infectious Diseases, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Instituição:	Infectious Diseases Society of America (IDSA)
País:	Arlington/VA, USA
Publicação/Editora:	Clinical Infectious Diseases 2010; 50:e26–e29
Data da publicação:	01/03/2010
Número de Páginas:	4
Veiculação no PEC:	09/02/2010 17h49
Resumo:
We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5′flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)–infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony‐forming units was comparable to standard 4‐h infusion of amphotericin B.
Arquivo para Download:
PEC-SBI_Micol Clin_Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis.pdf
Links Relacionados:
http://www.journals.uchicago.edu/doi/full/10.1086/650489

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